Fig. 2: HPMSCs expression profile of cytokines.
From: 3D spheroids of human placenta-derived mesenchymal stem cells attenuate spinal cord injury in mice
A The analysis of MSC-secreted cytokines in terms of inflammation (IL-4, IL-10, IL-11 and IL-13) and angiogenesis (VEGF) through RT-PCR. B 3D-HPMSCs promoted the secretion of anti-inflammatory factors (IL-4, IL-10, and IL-13), and inhibited pro-inflammatory factor TNF-a secretion compared with 2D-HPMSCs. C 3D-HPMSCs inhibited the secretion of chemokine (Eotaxin, Rantes, and IP-10) compared to 2D-HPMSCs. D 3D-HPMSCs also contributed to the secretion of trophic factors (PDGF-bb, VEGF, FGF basic, and G-CSF). B Enzyme-linked immunosorbent assay, C, D Bio-Plex ProTM cytokine assay, ∗, ∗∗, and ∗∗∗ indicate P < 0.05, P < 0.01, and P < 0.001, respectively.
