Fig. 3: Effects of microglial replacement on blood-brain barrier integrity after ICH in the aged mice. | Cell Death & Disease

Fig. 3: Effects of microglial replacement on blood-brain barrier integrity after ICH in the aged mice.

From: Microglial replacement in the aged brain restricts neuroinflammation following intracerebral hemorrhage

Fig. 3

ICH was induced in mice by injection of collagenase. A Brain sections from ICH mice in microglial repopulation group or control group were stained with CD31 (green), Claudin-5 (red), and ZO-1 (red) at day 3 after ICH. Scale bar: 20 µm. B Summarized results show that microglial repopulation had reduced Claudin-5 and ZO-1 loss in immunofluorescence intensity within the lesion area after ICH in aged mice. n = 10 sections from two mice per group. Data are presented as mean ± SD. **p < 0.01.

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