Fig. 1: TTK is a key gene regulating the cell cycle pathway that contributes to the oncogenesis and chemoresistance of HGSOC. | Cell Death & Disease

Fig. 1: TTK is a key gene regulating the cell cycle pathway that contributes to the oncogenesis and chemoresistance of HGSOC.

From: TTK inhibition increases cisplatin sensitivity in high-grade serous ovarian carcinoma through the mTOR/autophagy pathway

Fig. 1

A Two GEO datasets (GSE14407 and GSE10971) were used to distinguish genes related to the oncogenesis of serous ovarian carcinoma (log2 FC > 1; P < 0.001). B The KEGG pathway analysis of overlapping genes in (A). C The mRNA expression of TTK in ovarian cancer (n = 426) and normal control tissues (n = 88) from the GEPIA database. D RT–qPCR analysis showing the TTK mRNA level in HGSOC and the comparison to FT tissues (FT, n = 11; HGSOC, n = 20). E The level of the TTK protein in HGSOC and FT tissues was detected using western blot assays (FT, FT1-FT6; HGSOC, OC1-OC10). F Representative IHC images of TTK staining in HGSOC and FT tissues (×400), scale bar: 25 µm. G, H The TTK mRNA level in cisplatin-resistant A2780 (GSE15709) and SKOV3 (GSE98559) cells. I, J PFS (I) and OS (J) analyses using the K−M plotter database based on TTK expression (data are mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, n = 3).

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