Fig. 8: Knockdown of TTK increases cisplatin sensitivity by inhibiting autophagy in vivo. | Cell Death & Disease

Fig. 8: Knockdown of TTK increases cisplatin sensitivity by inhibiting autophagy in vivo.

From: TTK inhibition increases cisplatin sensitivity in high-grade serous ovarian carcinoma through the mTOR/autophagy pathway

Fig. 8

CAOV3 cells transfected with shTTK2 or PLKO.1 were subcutaneously injected into the left armpit of each 5-week-old female mouse. When the tumor volumes were approximately 100 mm3, each group of mice was randomly divided into two subgroups and treated with or without CDDP (2 mg/kg) for 14 days. A Photographs of tumors from each group. B The tumor weights in each group. C The bodyweight of each group in (A). D Representative images of IHC staining of TTK, Ki67, LC3B, and cleaved caspase-3 in tumor tissues (×400). Scale bar: 50 µm (data are mean ± SEM, #P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, n = 6).

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