Fig. 3: GDEs and multiple cell types in glioma TME. | Cell Death & Disease

Fig. 3: GDEs and multiple cell types in glioma TME.

From: Current landscape of tumor-derived exosomal ncRNAs in glioma progression, detection, and drug resistance

Fig. 3

There are many types of cells in the TME, roughly divided into four parts: (1) Tumor cells: glioma cell, GSC; (2) nerve cells: astrocyte, microglia, neuron, oligodendrocyte; (3) immune cells: macrophage, MDSC, DC, T cell, B cell, NK cell; (4) stroma cells: EC, pericyte. Especially, the GDEs mediate the intercellular communication in TME and can cross the BBB, which are expected to be novel targets for the treatment and diagnosis of glioma. GDE Glioma-derived exosome, TME tumor microenvironment, GSC glioma stem cell, MDSC myeloid-derived suppressor cell, DC dendritic cell, NK natural killer, EC endothelial cell, BBB blood-brain barrier.

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