Fig. 4: FDI-6 and Olaparib regulate cell cycle progression and DNA damage repair as indicated by the RNA sequencing analysis. | Cell Death & Disease

Fig. 4: FDI-6 and Olaparib regulate cell cycle progression and DNA damage repair as indicated by the RNA sequencing analysis.

From: FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair

Fig. 4

A Volcano plot shows DEGs induced by FDI-6 and/or Olaparib. GO enrichment (B) and KEGG pathway enrichment (C) analysis of DEGs. D Heatmap plot of the five DEGs. E The PPI network was used to analyze the interactions among PARP1, PARP2, the five proteins, and other proteins expanded from the STRING database using Cytoscape 3.7.

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