Fig. 2: Dynamic changes of high abundant miRNAs and their epigenetic regulation during mouse liver development. | Cell Death & Disease

Fig. 2: Dynamic changes of high abundant miRNAs and their epigenetic regulation during mouse liver development.

From: Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development

Fig. 2

A Cluster analysis of differentially expressed miRNAs during mouse liver development. B Changes in the most highly expressed miRNAs during mouse liver development. C Increase or decrease of miRNA of adult liver compared with e12.5; left Y-axis: increased or decreased FPKM (log2), right Y-axis: log2-fold change. D Hockey stick plots of H3K27ac signals of mouse liver at different developmental stages, super-enhancer-associated miRNAs are highlighted. E ChIP-seq profiles of H3K27ac near super-enhancer-associated miRNA loci of mouse liver at different developmental stages. The predicted super-enhancers regions are depicted as red bars. The y-axis represents reads per million (rpm) of ChIP-seq.

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