Fig. 1: Upregulation of HMGA1 and MYH9 was correlated with the progression of gliomas. | Cell Death & Disease

Fig. 1: Upregulation of HMGA1 and MYH9 was correlated with the progression of gliomas.

From: HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas

Fig. 1

A, B HMGA1 (A) and MYH9 (B) mRNA expression were upregulated in glioma tissues compared to normal brain tissues, and overexpressed levels of HMGA1 and MYH9 in glioma patients were positively correlated with the status of pathological classification. C The expression of HMGA1 was positively related to MYH9 expression. D Immunohistochemistry assay identified HMGA1 was overexpressed in glioma sample tissues compared to normal brain tissues. E MYH9 was overexpressed in glioma sample tissues. Strong expression of MYH9 was mainly observed in cytoplasmic (B, D, and E) and partly found in the nucleus (C and F) in glioma tissues. F, G Analysis of Chinese Glioma Genome Atlas (CCGA) database suggested HMGA1 (F) and MYH9 (G) mRNA level was significantly increased with the increase of WHO grade. H The expression of HMGA1 was positively related to MYH9 expression in CCGA database. I Dose–response curves of TMZ treatment were examined for HMGA1-overexpression groups and the control groups. J Western blot assay confirmed the change of the downstream pathway of HMGA1.

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