Fig. 2: Multivariate COX-regression and ROC analysis.
From: The role of RIPK1 mediated cell death in acute on chronic liver failure
These figures delineate the prognostic relevance of RIPK3 levels. A Multivariate Cox-regression analysis in 311 patients with acute decompensation (derivation cohort) considered age, MELD score, WBC, ACLF grade and RIPK3 levels as confounders for 28-day mortality. RIPK3 levels (HR 1.035; 95% CI 1.002–1.068; p = 0.037) and WBC (HR 1.081; 95% CI 1-026 1.026–1.138; p = 0.003) remained as independent predictors. B Thereafter, the predictive power (AUROC) of RIPK3 to predict 28-day and 90-day mortality and progression to ACLF was calculated by ROC analysis in the derivation and validation cohorts. The AUROC of RIPK3 to predict progression to ACLF was 0.650 (95% CI 0.562–0.738) in the derivation cohort and 0.744 (95% CI 0.595–0.892) in the validation cohort. The discrimination power (AUROC) of RIPK3 to predict survival was 0.768 (95% CI, 0.679–0.858) and 0.676 (95% CI, 0.595–0.758) at 28 and 90 days in the derivation cohort and 0.653 (95% CI, 0.530–0.776) and 0.696 (95% CI, 0.593–0.799) in the validation cohort, respectively.
