Fig. 5: TRPV1 deficiency alleviates mice EAE.
From: TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia
EAE was induced by active immunization of WT and TRPV1-KO C57BL/6 mice (n = 12 per group) with MOG35-55 peptide, and disease was scored from onset. A Clinical scores and (B) disease incidence for EAE from two genotypes. C–H Representative images of the spinal cord tissue sections of WT and TRPV1-KO mice after EAE induction using immunohistochemical staining. C, D Hematoxylin and eosin (H&E), (G, H) luxol fast blue (LFB), and (E, F) Iba-1 staining of lumbar spinal cord tissue sections of WT and TRPV1-KO EAE mice. Scale bar: 25 μm. Representative images from n = 3 mice per group are displayed. I, J Representative images of transmission electron microscopy showing the myelin sheath of spinal cord tissue from WT and TRPV1 KO mice after EAE induction. Scale bars: 5 μm. Representative images from n = 3 mice per group are displayed. **p < 0.01. ***p < 0.001.
