Fig. 4: Knockdown of ALDH3B2 inhibited CCA cell metastasis ability in vivo. | Cell Death & Disease

Fig. 4: Knockdown of ALDH3B2 inhibited CCA cell metastasis ability in vivo.

From: Aldehyde dehydrogenase 3B2 promotes the proliferation and invasion of cholangiocarcinoma by increasing Integrin Beta 1 expression

Fig. 4

A ALDH3B2 knockdown cells and scramble cells were injected via the tail vein of BALB/c nude mice. The body weights of mice injected with the scramble and shALDH3B2 cells were measured weekly. Mice injected with ALDH3B2 knockdown cells afforded less tumor burden. B Metastatic models were established by tail vein injection of scramble or ALDH3B2-knockdown RBE cells. The tumor metastases were monitored by a live imaging system. C The statistical analysis of radiant efficiency of in vivo fluorescence in mice injected with scramble or ALDH3B2 knockdown cells (n = 6). D Statistical analysis of liver weight in mice injected with scramble and shALDH3B2 cells. E Representative gross specimens (upper panel) and HE staining (middle and lower panel) of metastasis lesions in liver and lung. Scale bar: 500 μm. F, G Statistical analysis of numbers of metastatic nodules in liver (F) and lungs (G) of mice. **p < 0.01, ***p < 0.001.

Back to article page