Cell Death & Disease

Table 2 The prognostic significance of ALDH3B2 and clinicopathological characteristics in CCA.

From: Aldehyde dehydrogenase 3B2 promotes the proliferation and invasion of cholangiocarcinoma by increasing Integrin Beta 1 expression

Characteristics	iCCA				pCCA				dCCA
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	3-year OS	p^a	HR	p^b	3-year OS	p^a	HR	p^b	3-year OS	p^a	HR	p^b
Age (years)
<60	36.5	0.132			41.9	0.029	1		45.4	0.127
≥60	9.1				21.6		2.355	0.009	32.6
Gender
male	31.3	0.794			32.6	0.358			30.7	0.364
female	18.2				20.5				47.2
Tumor size
<3 cm	14.3	0.246			33.8	0.157			37.9	0.131
≥3 cm	28.6				21.0				29.6
Differentiation
Well/moderate	23.4	0.710			32.3	0.051	1		41.0	0.554
Poor	27.3				21.9		1.874	0.036	29.3
T stage
T1/T2	34.3	0.032	1		29.7	0.014	1		47.8	0.009	1
T3/T4	0		2.708	0.041	0		3.822	0.022	26.6		1.648	0.084
N stage
N0	29.3	0.083	1		40.4	0.003	1		39.3	0.032	1
N1/N2	0		0.890	0.885	5.5		1.381	0.334	30.9		1.418	0.256
M stage
M0	29.8	0.252			33.7	<0.001	1		38.0	<0.001	1
M1	0				0		2.788	0.008	0		3.588	0.048
TNM stage
I/II	34.3	0.032			37.5	0.004			36.4	0.204
III/IV	0				7.1				42.1
Neural invasion
Negative	21.8	0.348			42.1	0.221			48	0.006	1
Positive	40.0				19.3				28.3		1.994	0.021
CEA (ng/ml)
<10	35.5	0.006	1		30.4	0.022	1		38.2	0.070	1
≥10	0		2.003	0.214	0		2.630	0.027	0		1.817	0.292
CA19-9 (U/mL)
<100	43.6	0.027	1		36.1	0.020	1		47.7	0.108
≥100	12.5		2.619	0.054	22.6		1.182	0.586	25.8
ALDH3B2
Low	38.5	0.038	1		36.9	0.001	1		42.3	0.025	1
High	10.7		2.542	0.047	16.3		1.905	0.042	28.5		1.590	0.096

ALDH3B2 aldehyde dehydrogenase 3B2, CCA cholangiocarcinoma, OS overall survival, HR hazard ratio.
^a Calculated by log-rank test.
^b Calculated by Cox-regression Hazard model.

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