Fig. 8: Sidt2 deletion causes renal autophagy, structure, and function impairments. | Cell Death & Disease

Fig. 8: Sidt2 deletion causes renal autophagy, structure, and function impairments.

From: Sidt2 is a key protein in the autophagy-lysosomal degradation pathway and is essential for the maintenance of kidney structure and filtration function

Fig. 8

The deletion of Sidt2 gene leads to lysosomal acidification disorders, and the fusion of autophagosomes and lysosomes is blocked, which leads to the formation and degradation barriers of autophagolysosomes. Impaired autophagy ultimately leads to impaired kidney structure and filtration function.

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