Fig. 7: HuR participates in regulating METTL14 transcription control. | Cell Death & Disease

Fig. 7: HuR participates in regulating METTL14 transcription control.

From: TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4

Fig. 7

A The protein expression levels of YTHDF2, HuR and METTL14 in METTL14-knockdowned SW480 cells were detected by western blotting. B, C The effect of YTHDF2 and HuR loss or overexpression on METTL14 protein expression in CRC cells were measured by western blotting, respectively. D Relative mRNA expression of METTL14 in CRC cells with HuR knockdown or overexpression were measured by qRT-PCR. E ChIP assay was performed in SW480 and HCT15 cells to determine whether HuR could bind to the promoter of METTL14. F Immunoblotting analysis of HuR in 14 pairs CRC tissue and para-cancerous tissue. G Representative IHC staining images of HuR in tumor and adjacent normal samples. H The correlation of HuR and METTL14 expression in CRC tissue. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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