Fig. 6: Positive association of USP3 expression with COL9A3 and COL6A5 expression, and the effect of the regulatory axis on prognosis of GC patients. | Cell Death & Disease

Fig. 6: Positive association of USP3 expression with COL9A3 and COL6A5 expression, and the effect of the regulatory axis on prognosis of GC patients.

From: USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation

Fig. 6

A Western blot analysis of USP3, COL9A3 and COL6A5 levels in human GC tissues and adjacent normal tissues. B Representative images of USP3, COL9A3 and COL6A5 expressions in 94 samples of either normal or cancerous gastric tissues, which were detected by TMA analysis. Scale bars, 200 μm. C Scatter plot analysed the expression levels of USP3, COL9A3 and COL6A5 in GC tissues compared with the corresponding adjacent normal tissues. D, E Linear regression analysis and Pearson’s correlation were used to determine the relationship between USP3 and COL9A3/COL6A5 protein expression in gastric cancerous tissue specimens. F, G Kaplan-Meier curves for overall survival analysis of GC patients according to the associations between expression levels of USP3 and COL9A3/COL6A5.

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