Fig. 4: Inhibition of miR-24-3p enhances intestinal epithelial cell apoptosis during the recovery from colitis. | Cell Death & Disease

Fig. 4: Inhibition of miR-24-3p enhances intestinal epithelial cell apoptosis during the recovery from colitis.

From: Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation

Fig. 4

A, B After TUNEL labeling of Swiss rolls, the central and distal epithelium were annotated with software and the total number of TUNEL-positive nuclei (green) were quantified and compared to the total number of nuclei (blue). Scale bars = 100 µm. n = 4 mice for control inhibitor, n = 6 mice for miR-24-3p inhibitor from two independent experiments. Mean ± SD. *p < 0.05. C Representative Ki67 immunohistochemistry images of epithelial cells surrounding the ulcerated epithelium. Scale bars = 150 µm. D A graph representing a pathologist’s assessment of Ki67 positive cells surrounding the ulcer. n = 10 for wild type mice, n = 9 for miR-24-3p knockout mice from two independent experiments. Mean ± SD.

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