Fig. 6: MET prevents MGO-induced apoptosis by modulating the PI3K/Akt and Nrf2/HO-1 pathways in vivo. | Cell Death & Disease

Fig. 6: MET prevents MGO-induced apoptosis by modulating the PI3K/Akt and Nrf2/HO-1 pathways in vivo.

From: Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo

Fig. 6

C57BL/6 mice were treated with MGO and MET, after which the aortas were collected for biochemical parameters. A, B Histological changes in the aortas were evaluated by H&E staining. C, D Apoptosis was evaluated by TUNEL staining. E, F The proapoptotic factor cleaved caspase-3 was evaluated by Immunohistochemistry staining. G, H Nrf2 expression was evaluated by Immunohistochemistry staining. I, J The phosphorylation of Akt was also determined by Immunohistochemistry staining. Data are presented as the mean ± SD, n ≥ 5 for each group. **p < 0.01, ***p < 0.001. Bar = 50 μm.

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