Fig. 6: SNAI2 promotes in vivo tumorigenesis of glioma by inhibiting the PHLPP2 to activate the Akt pathway. | Cell Death & Disease

Fig. 6: SNAI2 promotes in vivo tumorigenesis of glioma by inhibiting the PHLPP2 to activate the Akt pathway.

From: Transcription factor SNAI2 exerts pro-tumorigenic effects on glioma stem cells via PHLPP2-mediated Akt pathway

Fig. 6

A The weight of tumor xenografted in nude mice in the presence of oe-NC, oe-SNAI2, oe-PHLPP2, or oe-SNAI2 + oe-PHLPP2. B The volume of tumor xenografted in nude mice in the presence of oe-NC, oe-SNAI2, oe-PHLPP2, or oe-SNAI2 + oe-PHLPP2. C p-Akt level in the presence of oe-NC, oe-SNAI2, oe-PHLPP2, or oe-SNAI2 + oe-PHLPP2 in nude mice xenografted with tumor as determined by Western blot assay. *p < 0.05 vs. nude mice xenografted with tumor injected with GSCs expressing oe-NC, si-NC, oe-SNAI2, or oe-PHLPP2. Each cell experiment was repeated three times independently. n = 10.

Back to article page