Fig. 4: Knockdown of NK1R impaired NSCLC tumor growth in vivo. | Cell Death & Disease

Fig. 4: Knockdown of NK1R impaired NSCLC tumor growth in vivo.

From: Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR

Fig. 4

A549 and NCI-H1944 cells were transfected with control or shNK1R plasmid. A, B The effect of NK1R knockdown on NSCLC tumor growth in nude mice. C Western blot and D IHC analysis of NK1R and Ki67 protein level in xenograft tumor samples. Scar bar, 50 μm. The IHC staining and densitometric analysis of each band were calculated with Image J software. Data were shown as mean ± SD from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.

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