Fig. 4: POLE2 knockdown suppresses GBM growth in vivo. | Cell Death & Disease

Fig. 4: POLE2 knockdown suppresses GBM growth in vivo.

From: POLE2 facilitates the malignant phenotypes of glioblastoma through promoting AURKA-mediated stabilization of FOXM1

Fig. 4

A In vivo imaging was performed to evaluate the tumor burden in mice of shPOLE2 and shCtrl groups post tumor-inoculation B–C U87 cells with or without POLE2 knockdown, the volume (B) and weight (C) of tumors formed in mice was measured and calculated at indicated time intervals. D photo of the removed tumors was taken post tumor-inoculation. E The Ki67 level in tumors removed from mice was detected by IHC as a representation of tumor growth. Data were shown as mean ± SD. *P < 0.05, **P < 0.01.

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