Fig. 5: POLE2 knockdown regulates AURKA-mediated FOXM1 ubiquitination. | Cell Death & Disease

Fig. 5: POLE2 knockdown regulates AURKA-mediated FOXM1 ubiquitination.

From: POLE2 facilitates the malignant phenotypes of glioblastoma through promoting AURKA-mediated stabilization of FOXM1

Fig. 5

A–B The protein stability of FOXM1 in U87 and U251 cells after POLE2 knockdown (A) or AURKA knockdown (B) was examined. C–D After treatment with MG-132, levels of FOXM1 proteins in U87 and U251 cells with POLE2 (C) or AURKA (D) knockdown was examined. E The lysates of U87 and U251 cells were immunoprecipitated and WB was performed to examine the ubiquitination of FOXM1. F Co-IP analysis of interaction of POLE2 and FOXM1 in U87 and U251 cells. The representative images were selected from at least three independent experiments.

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