Fig. 1: Landscape of single cells derived from nccRCC and normal tissues.

A Sixteen major cell types identified by scRNA-seq; B sample origin (Tumor or normal); C immune cells (PTPRC+ or CD45+) or nonimmune cells; D the results of ESTIMATE algorithm: Tumor purity, Stromal score, Immune score of different cells; E for 34 subgroups identified in this landscape (left to right): the fraction of cells originating from 11 tumor and 4 normal samples, and the fraction of cells originating from each of 6 patients; F the bubble plot of top5 genes expression in each cell cluster; the size of bubble represents the percent expressed of cells; the color represents the average expression of each gene in clusters: red means the high expression.