Fig. 6: Clinical value of cell clusters of TME recognized by our scRNA-seq analysis in patients of TCGA nccRCC cohort. | Cell Death & Disease

Fig. 6: Clinical value of cell clusters of TME recognized by our scRNA-seq analysis in patients of TCGA nccRCC cohort.

From: Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study

Fig. 6

A Forest plot of cell clusters calculated by CIBERSORTx and overall survival (left) and progression-free survival (right); hazard ratios (HRs), with their 95% confidence intervals. B–D Kaplan–Meier survival curve for patients in TCGA nccRCC. Log rank p value <0.05 was considered as statistically significant; E Boxplots showed that CD8T_cluster3_cells, sarRCC_cells and chrRCC-derived macrophages were enriched in high-TNM stage; F Nomogram plot presented the prognostic role of significant cell clusters combined with clinical factors; G nccRCC patients from TCGA nccRCC were divided into three clusters by ConsensusClusterPlus according to cell clusters recognized in this landscape; H Survival analysis of three patient clusters. Log rank p value was calculated in GraphPad Prism 7.0; I Relative abundance of CD8T_cluster3_cells, sarRCC_cells and chrRCC-derived macrophages in three patient clusters. Tukey’s multiple comparison test was used.

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