Fig. 8: The mechanism of FIRRE in CRC progress. | Cell Death & Disease

Fig. 8: The mechanism of FIRRE in CRC progress.

From: LncRNA FIRRE functions as a tumor promoter by interaction with PTBP1 to stabilize BECN1 mRNA and facilitate autophagy

Fig. 8

FIRRE which is localized in the nucleus binds to PTBP1 protein, promoting the translocation of PTBP1 from nucleus to cytoplasm. The RNA-protein complex in cytoplasm interacts with the 3' end of BECN1 mRNA. This interaction enhances the stability of BECN1 mRNA under treatment of ACD and the activity of autophagy, which contributes to the development of CRC.

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