Fig. 1: EVs-mediated drug-resistance mechanism of OC.
From: Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion
Drug-resistant cells excrete chemotherapeutic drugs out of the cell by secreting EVs to achieve the purpose of chemotherapy resistance. At the same time, the ncRNA and active protein contained in the EVs secreted by the drug-resistant cells enter the sensitive cells through endocytosis, thereby transmitting the drug-resistant phenotype. We use EV miR-21 [49] as an example to demonstrate the emergence of this resistance mechanism. EVs secreted by drug-resistant cells also change the tumor microenvironment, making tumor cells more likely to survive.
