Table 2 EV noncoding RNA biomarkers proposed for monitoring OC chemoresistance.

From: Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion

Cargo type

Sample origin

EV cargo

Pathway/Mode of action

Reference

MiRNA

Serum

MiR-214-3p

Inhibit the expression of LHX6

[56]

Plasma

MiR-891-5p

Increase the expression of G2/M checkpoints

[46]

Serum

MiR-484

Regulate angiogenesis

[63]

Macrophages

MiR-223

Inhibit the expression of PTEN to activate the PI3K/AKT pathway

[51]

LncRNA

SKOV3.ip1, HO8910.PM

LncRNA MALAT1

Regulate angiogenesis

[64]

Serum

LncRNA UCA1

Inhibit the expression of miR-143 thereby upregulating FOSL2

[59]

CircRNA

Serum

CircRNA Cdr1as

Inhibit the expression of miR-1270thereby upregulating SCAI

[66]

SKOV3

CircRNA Foxp1

Upregulate the expression of CEBPG and FMNL3 through miR-22 and miR-150-3p

[65]

  1. Abbreviations: AKT also known as PKB, protein kinase B; Cdr1as cerebellar degeneration-related protein 1 antisense RNA, CEBPG CCAAT enhancer binding protein gamma, EV extracellular vesicles, FMNL3 formin like 3, FOSL2 Fos-likeantigen2, Foxp1 forkhead box P1, LHX6 LIM homeobox 6, MALAT1 metastasis associated lung adenocarcinoma transcript 1, PI3K phosphatidylinositol 3-kinase, PTEN Phosphatase and tensin homolog, UCA1 urothelial cancer associated 1.
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