Fig. 1: HERC3 is identified to exert an important role in CRC through bioinformatics analysis. | Cell Death & Disease

Fig. 1: HERC3 is identified to exert an important role in CRC through bioinformatics analysis.

From: HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer

Fig. 1

a Venn plots showed the overlap of the upregulated and downregulated E3s based on differential analysis respectively (left panel). Heatmap showed the expression pattern of the 24 differentially expressed E3s in diverse datasets. b Expression pattern of HERC3 in TCGA CRC tissues and in the dataset that was compounded by colon epithelial tissues from GTEx and CRC normal tissues from TCGA (left panel). Expression pattern of HERC3 in colonic epithelial tissues from GTEx, CRC patient adjacent-normal tissues and CRC patient tumor tissues from TCGA (right panel). c Overall survival (OS) and disease-free survival (DFS) analysis in CRC patients from TCGA based on the expression of HERC3. Patients were divided into two groups according to the median expression of HERC3. Survival analysis were visualized by Kaplan-Meier plots and tested by log-rank. P < 0.05 was identified as statistically significant.

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