Fig. 6: Nogo-B promotes NPC cell migration by regulating RhoA-SRF-MRTFA.
From: Nogo-B promotes invasion and metastasis of nasopharyngeal carcinoma via RhoA-SRF-MRTFA pathway
A The STRING database showed that Nogo-B and RhoA were associated. B Real-time PCR showed that RhoA, MRTFA, and SRF were highly expressed in TW03 (left) and HK1 (right) cell lines overexpressing Nogo-B and NgR3. C Western blotting showed that RhoA-GTP, MRTFA, and SRF were highly expressed in TW03 (left) and HK1 (right) cell lines overexpressing Nogo-B and NgR3. D Immunohistochemistry showed that overexpressing NgR3 and Nogo-B upregulated p-RhoA expression in metastatic mouse lung xenografts. E After treatment with CCG-1423(30 μmol/L) for 24 h, the expression of FAK and N-Cadherin decreased in HK1 cell lines. F The average number of migrated cells in three fields of HK1 cell lines with overexpressing Nogo-B or NgR3 decreased after using CCG-1423(30 μmol/L). G The average number of invaded cells in three fields of HK1 cell lines with overexpressing Nogo-B or NgR3 decreased after using CCG-1423(30 μmol/L).
