Fig. 7: Nogo-B+ p-RhoA+ correlates with a poor prognosis of NPC.
From: Nogo-B promotes invasion and metastasis of nasopharyngeal carcinoma via RhoA-SRF-MRTFA pathway
A Nogo-B expression was positively correlated with p-RhoA expression in NPC tissues. Left, representative images of two NPC patients were shown. Right, a positive correlation was found between Nogo-B expression and p-RhoA expression. B The 3-year OS rate of 89 Nogo-B+ p-RhoA+ NPC patients was 82.0%. Kaplan–Meier and log-rank test analysis showed that the cumulative 3-year OS rate was 92.5% in the low Nogo-B or p-RhoA expression group (blue line) and 66.7% in the Nogo-Bhigh p-RhoAhigh group (red line) (P = 0.003). C The 3-year PFS rate of 89 Nogo-B+ p-RhoA+ NPC patients was 80.9%. Kaplan–Meier and log-rank test analysis showed that the cumulative 3-year PFS rate was 63.9% in the Nogo-Bhigh p-RhoAhigh group (red line) and 92.5% in the other group (blue line) (P = 0.001).
