Fig. 1: BMP-7 ameliorated renal fibrosis in diabetic mice. | Cell Death & Disease

Fig. 1: BMP-7 ameliorated renal fibrosis in diabetic mice.

From: BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease

Fig. 1

a Rescue experiment design. At 6 weeks after the diabetic mice model had been successfully established, OE-BMP-7 plasmid was injected i.v. every week for 6 consecutive weeks, and mice were killed at the end of 12 weeks.b Urinary microalbumin/urinary creatinine level in NC + Control group and the DM group (DM + Control, DM + Vector, DM + BMP-7) mice,*P < 0.05 (n = 6). c Blood glucose, d Triglyceride, e Total cholesterol levels in the NC group (NC + Control, NC + Vector, NC + BMP-7) and DM group (DM + Control, DM + Vector, DM + BMP-7) mice,*P < 0.05 (n = 6). Histological changes of kidneys in the NC group and DM group f (hematoxylin-eosin staining), g (Masson’s trichrome staining)black box indicates the enlarged area of details for fibrosis(magnification ×400). h Renal tubular lumen area was analyzed in each group from six random fields (200×), *P < 0.05 (n = 6). i Positive staining density of Masson’s trichrome staining was analyzed in each group from six random fields (200×), *P < 0.05 (n = 6).

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