Fig. 4: E3330 enhanced the proapoptotic capacity of vemurafenib in BCPAP and K-1 cells. | Cell Death & Disease

Fig. 4: E3330 enhanced the proapoptotic capacity of vemurafenib in BCPAP and K-1 cells.

From: Pharmacological inhibition of Ref-1 enhances the therapeutic sensitivity of papillary thyroid carcinoma to vemurafenib

Fig. 4

A, B The cell apoptosis rate measured by flow cytometric analysis in BCPAP and K-1 cell lines. C, D The mitochondrial membrane potential evaluation by detecting JC-1 content in BCPAP and K-1 cell lines. E, F Mitochondrial apoptosis pathway-associated protein expression detection by western blot assay in BCPAP and K-1 cell lines. BCPAP and K-1 cell lines were pretreated with DMSO, vemurafenib (10 μM), E3330 (50 μM), and combination (10 μM vemurafenib + 50 μM E3330), respectively. *P < 0.05, **P < 0.01, ***P < 0.001.

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