Fig. 8: Overall schematic diagram. | Cell Death & Disease

Fig. 8: Overall schematic diagram.

From: The feedback loop of ANKHD1/lncRNA MALAT1/YAP1 strengthens the radioresistance of CRC by activating YAP1/AKT signaling

Fig. 8

There is an ANKHD1/MALAT1/YAP1-feedback loop in CRC cells, which synergistically regulates the nuclear translocation of YAP1 and promotes the transcriptional coactivation of YAP1. Subsequently, YAP1-mediated activation of AKT increases the expression of the MRN complex and then activates the ATM/CHK2-checkpoint pathway, promoting DNA damage repair and ultimately resulting in radioresistance in CRC.

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