Fig. 3: ARL6IP5 inhibited cellular proliferation, invasion, migration, and adhesion in OC and CisR OC cells. | Cell Death & Disease

Fig. 3: ARL6IP5 inhibited cellular proliferation, invasion, migration, and adhesion in OC and CisR OC cells.

From: ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma

Fig. 3

A CisR cells were generated from OC cells via gradual increments of cisplatin treatment for 8 months. Cell viability and IC50 of OC and CisR OC cells following exposure to cisplatin were determined. The IC50 of the resulting CisR cells were over five times greater than the parental OC cells. B OC and CisR OC cells were transfected with empty vector, si-NC (for negative control), pcARL6IP5 (ARL6IP5 + + ; for overexpression), and si-ARL6IP5 (for knockdown). Effects of ARL6IP5 overexpression and knockdown on cellular C proliferation, D invasion, E migration, F adhesion in OC and CisR OC cells (original magnification, ×10; scale bar, 100 µm). *p < 0.05 compared with empty vector; #p < 0.05 compared with si-NC.

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