Fig. 3: Loss of HDAC1 represses CC cell migration and invasion in vivo and in vitro. | Cell Death & Disease

Fig. 3: Loss of HDAC1 represses CC cell migration and invasion in vivo and in vitro.

From: Suppression of histone deacetylase 1 by JSL-1 attenuates the progression and metastasis of cholangiocarcinoma via the TPX2/Snail axis

Fig. 3

A Wound healing ability of TFK-1 cells upon HDAC1 silencing evaluated by scratch test. B TFK-1 cell migration upon HDAC1 silencing assessed by Transwell assay. C TFK-1 cell invasion upon HDAC1 silencing tested by Transwell assay. D Program flowchart of tumor metastasis model developed in nude mice and HDAC1 silencing. E The number of nodules visualized on the liver surface in tumor-bearing nude mice in response to HDAC1 silencing. F Analysis for HE staining of nodules in the liver of tumor-bearing nude mice in response to HDAC1 silencing. *p < 0.05. In panels (A–D), data were compared by one-way ANOVA with Tukey’s post hoc test. In panels (E) and (F), data were compared by unpaired t-test. The cell experiment was independently repeated three times. n = 6 for animal experiment.

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