Fig. 5: HDAC1 knockdown represses the migratory, invasive and metastatic properties of CC cells via suppression of TPX2. | Cell Death & Disease

Fig. 5: HDAC1 knockdown represses the migratory, invasive and metastatic properties of CC cells via suppression of TPX2.

From: Suppression of histone deacetylase 1 by JSL-1 attenuates the progression and metastasis of cholangiocarcinoma via the TPX2/Snail axis

Fig. 5

A Cell migration and invasion upon HDAC1 silencing alone or with TPX2 overexpression in combination assessed by Transwell assay. B Program flowchart of tumor metastasis model developed in nude mice and HDAC1 silencing alone or with TPX2 overexpression in combination. C The number of nodules on the mouse liver surface. D The number of nodules inside the mouse liver. *p < 0.05. Data were compared by one-way ANOVA with Tukey’s post hoc test. The cell experiment was independently repeated three times. n = 6 for animal experiment.

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