Fig. 6: Suppression of Fascin inhibits ferroptosis in vivo.
From: Fascin enhances the vulnerability of breast cancer to erastin-induced ferroptosis
Four-week-old immunodeficient nude mice (five mice per group) were subcutaneously injected with the indicated MDAMB231 cells infected with control or Fascin shRNAs (1 × 106 cells per mouse) and treated with erastin (20 mg per kg intraperitoneal, twice every other day) at day seven. A Tumour growth curves. B Isolated subcutaneous tumours. C Tumour weight. D Representative images of IHC staining for Fascin, xCT, and 4HNE in the xenografts. E Schematic depicting the regulation of xCT by Fascin during ferroptosis. n.s. not significant. *p < 0.05, **p < 0.01, and ***p < 0.001. The data are displayed as the means ± s.d.
