Fig. 4: CSL311 significantly reduces netosis in response to LPS challenge in hβcTg mice. | Cell Death & Disease

Fig. 4: CSL311 significantly reduces netosis in response to LPS challenge in hβcTg mice.

From: Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models

Fig. 4

A Co-localisation of MPO (green) and histone H3 (red) staining identified lung netosis, which was more prominent with high dose LPS (10 μg). B MPO activity and (C) dsDNA levels were quantified in the BAL-fluid. D MPO activity and (E) dsDNA in BALF were significantly reduced with CSL311 treatment. n = 6–7; data are Mean ± SE; *p < 0.05, two-way ANOVA.

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