Fig. 6: CSL311 reduces lung inflammation and injury without compromising viral clearance in IAV-infected hβcTg mice. | Cell Death & Disease

Fig. 6: CSL311 reduces lung inflammation and injury without compromising viral clearance in IAV-infected hβcTg mice.

From: Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models

Fig. 6

CSL311 or isotype control (ISO) was administered to IAV-infected hβcTg mice at day 4 post infection. At day 7, IAV induced (A) body weight loss, which was not significantly improved by CSL311 treatment. (B) Lung viral load was measured by RTqPCR on viral PA gene and no difference was detected between CSL311 and ISO treated mice infected with IAV. Elevated levels of (C) blood monocytes, (D) blood neutrophils and (E) blood hemoglobin (HGB) induced by IAV infection were significantly reduced by CSL311. F BAL neutrophils and (G) BAL macrophages were also reduced with CSL311 treatment. H Representative photos of lungs identified severe hemorrhage of entire lung lobes (white arrows) in IAV-infected mice, which was less apparent in CSL311 treated mice (green arrow). n = 6; data are Mean ±SE except viral loads which are Median ± interquartile ranges; *p < 0.05, **p < 0.01, ***p < 0.001 one-way ANOVA except viral loads which are Mann–Whitney U test.

Back to article page