Fig. 7: CSL311 blocks lung myeloid cells and preserves NK cell and T cells in IAV-infected hβcTg mice. | Cell Death & Disease

Fig. 7: CSL311 blocks lung myeloid cells and preserves NK cell and T cells in IAV-infected hβcTg mice.

From: Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models

Fig. 7

Flow cytometry analysis utilizing a (A) gating strategy for myeloid cells revealed that lung (B) neutrophils, (C) alveolar macrophages (AMs), (D) exudative macrophages (EMs), (E) monocytes and (F) eosinophils were highly increased in hβcTg mice at day 6 post IAV infection, and significantly reduced with CSL311 treatment. Flow cytometry analysis utilizing a (G) gating strategy for delineating lymphoid cells demonstrated that lung (H) NK cells, (I) NKT cells and (J) regulatory T cells (Tregs) were increased following IAV infection and were not affected by CSL311 treatment. K Lung CD4 cells and (L) CD8 cell numbers in the lungs did not differ across all groups; n = 6; data are Mean ± SE; *p < 0.05, **p < 0.01, ***p < 0.001 one-way ANOVA.

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