Fig. 8: CSL311 attenuates lung cytokine storm and preserves interferon expressions in IAV-infected hβcTg mice. | Cell Death & Disease

Fig. 8: CSL311 attenuates lung cytokine storm and preserves interferon expressions in IAV-infected hβcTg mice.

From: Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models

Fig. 8

Expression of the neutrophil chemokine (A) Cxcl1, monocyte/macrophage chemokine (B) Ccl2, eosinophil chemokine (C) Ccl24, T cell/NK cell chemokine (D) Cxcl10 were detected by RTqPCR in the lungs of IAV-infected mice, where CSL311 significantly lowered Ccl2 and Ccl24 levels. Expression of the pro-inflammatory genes (E) Il1a and (F) Il6 were also increased in IAV-infected mice and CSL311 treatment significantly reduced Il1a but not Il6 expression. G Type I interferon (Ifnb), (H) type II interferon (Ifng) and (I) type III interferon (Ifnl2/3) were also markedly induced in the lungs of IAV-infected mice in a manner that was not significantly altered by CSL311 treatment; n = 6; *p < 0.05, data are Mean ± SE; **p < 0.01, ***p < 0.001 one-way ANOVA.

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