Fig. 1: Analysis of correlations between ROCK2, MGMT expressions and TMZ treatment responses in glioma patients in the CGGA database. | Cell Death & Disease

Fig. 1: Analysis of correlations between ROCK2, MGMT expressions and TMZ treatment responses in glioma patients in the CGGA database.

From: Acquired temozolomide resistance in MGMTlow gliomas is associated with regulation of homologous recombination repair by ROCK2

Fig. 1

A, B ROCK2 gene level in 693 case glioma patients as calculated by CGGA online tools. C Co-expression analysis of ROCK2 and MGMT mRNA expression in subset of recurrent gliomas. D Co-expression analysis of ROCK2 and MGMT mRNA expression in subset of recurrent gliomas with TMZ + Radiation therapy (n = 168). E Co-expression analysis of ROCK2 and MGMT mRNA expression in subset of recurrent gliomas with TMZ treatment (n = 24). F Co-expression analysis of ROCK2 and MGMT mRNA expression in subset of recurrent gliomas with radiation therapy (n = 22). G ROCK2 mRNA expression levels in recurrent gliomas using mRNA 637 data set. Recurrent group: TMZ-treatment MGMT− (n = 12), TMZ-treatment MGMT+ (n = 12), Radiation treatment MGMT− (n = 11), Radiation treatment MGMT+ (n = 11), TMZ + Radiation treatment MGMT− (n = 84), TMZ + Radiation treatment MGMT+ (n = 84). Primary group: without treatment, MGMT− (n = 27), MGMT (n = 26). H, I Survival analysis of recurrent MGMThigh and MGMTlow glioma patients with different ROCK2 expression. Statistical differences are given as *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001.

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