Fig. 5: ROCK2 directly regulated ATM expression. | Cell Death & Disease

Fig. 5: ROCK2 directly regulated ATM expression.

From: Acquired temozolomide resistance in MGMTlow gliomas is associated with regulation of homologous recombination repair by ROCK2

Fig. 5

A Co-expression analyze of ATM with ROCK2 using CGGA data. B Gene expressions of ATM was determined with ROCK2-KD. C, D ATM protein levels were determined with ROCK2-KD. E–H Gene and protein expressions of ATM and ROCK2 were determined with ROCK2-OE. I Gene expression of ATM was determined with ROCK2-tet-KD. J–L Protein expression of ATM was determined with ROCK2-tet-KD. Data are expressed as mean ± SD of three independent experiments. p values determined by ANOVA or two-tailed unpaired t-test. Statistical differences compared with the controls are given as *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001.

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