Fig. 6: ROCK2 directly regulated HR via ATM. | Cell Death & Disease

Fig. 6: ROCK2 directly regulated HR via ATM.

From: Acquired temozolomide resistance in MGMTlow gliomas is associated with regulation of homologous recombination repair by ROCK2

Fig. 6

HR efficiency was determined with supplementary of MRE11, RAD51, BRCA1 in U87R (A), U251R (B), mrU251 (C) and A172R (D) of ROCK2-KD clones cells. E HR efficiency was determined with supplementary of ATM in ROCK2 KD cells. F HR efficiency was determined with supplementary of ATM-tet-KD in ROCK2-OE cells. RAD51 levels at the site-specific DSB, G U87R, H U251R, I mrU251, J A172R. Data are expressed as mean ± SD of three independent experiments. p values determined by ANOVA or two-tailed unpaired t-test. Statistical differences compared with the controls are given as *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001.

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