Fig. 8: Autolysosomes control the biogenesis of apoptotic exosome-like vesicles (ApoExos), and caspase-3 controls their release.
From: Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
Autophagy plays a central role in the degradation of perlecan and the loading of perlecan fragments into ApoExos forming within large autolysosomes. Caspase-3 activation regulates fusion between autolysosomes and the plasma membrane, thereby controlling the secretion of immunogenic ApoExos. The schematic was created with BioRender.com.
