Fig. 3: DSS-treated Cd44Δie mice had increased intestinal inflammation and delayed regeneration. | Cell Death & Disease

Fig. 3: DSS-treated Cd44Δie mice had increased intestinal inflammation and delayed regeneration.

From: Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

Fig. 3

a Experimental design. b Daily body weight change (% of initial body weight) of Cd44Δie and Cd44+/+ mice subjected to 2.5% DSS or normal drinking water. The mean weight difference of the two DSS treated groups (Cd44Δie vs. Cd44+/+ mice) was compared for every timepoint separately. Error bars, ±SE. c Representative images of colons from DSS-treated Cd44Δie and Cd44+/+ mice. d Colon lengths from Cd44Δie and Cd44+/+ mice +/− DSS. Error bars, ±SE. e Disease activity index (DAI) of the mice described in b. Error bars, ±SE. f H&E staining of colon sections of the mice described in b. Scale bar: 200 µm. Asterisk: submucosa. Arrowheads: mucosa (a’–d’ is an enlargement of a–d). g Histological colitis score (HCS) of the mice described in b. Error bars, ±SE. Student’s t test; *p < 0.05, **p < 0.01, ***p < 0.001, ns = not significant, except Fig. 3e, g: Mann–Whitney U-test. IP intraperitoneal, TAM tamoxifen, N = number of mice.

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