Fig. 8: Graphical abstract.
From: Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop
Since CD44 is a Wnt target gene and a positive modulator of signal transduction of the Wnt pathway, it establishes a positive feedback loop to amplify Wnt signaling in the intestine acting at the level of the signalosome. Removal of Cd44 from the intestinal epithelium leads to decreased Wnt signaling still sufficient in homeostatic conditions but fails to increase Wnt activity as required in the regeneration of the intestinal epithelium after DSS damage.
