Fig. 1: Construction of a circular RNA-associated ceRNA regulatory network in C57BL/6 mice UUO model and screening for targeted circular RNA. | Cell Death & Disease

Fig. 1: Construction of a circular RNA-associated ceRNA regulatory network in C57BL/6 mice UUO model and screening for targeted circular RNA.

From: The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis

Fig. 1

A Overview of the targeted circular RNA mining and further validation of its ceRNA regulatory pathway. B Sankey diagram for the ceRNA network in UUO model. Each rectangle represents a circular RNA, microRNA, and mRNA, and the line connecting them represents form of a regulatory pathway. The connection degree of each gene is displayed based on the size of the rectangle. C List of selected circular RNAs (fold change >2, nucleotides <1000) from sankey diagram and the top 7 circular RNAs ranked by sequence conservation between human and mouse species. *Conservation of sequence was tested by blast function in circBase website (http://circrna.org/cgi-bin/webBlat). In the blast results, the higher scores, the more deemed homologous hsa_circ_RNA when identity >80%.

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