Fig. 4: NMN supplementation and Parkin overexpression can reduce the accumulation of damaged neuronal mitochondria caused by PrP106-126. | Cell Death & Disease

Fig. 4: NMN supplementation and Parkin overexpression can reduce the accumulation of damaged neuronal mitochondria caused by PrP106-126.

From: PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease

Fig. 4

A, B Western blots of mitochondrial protein (TOMM40, COXIV, SOD2) expressions in N2a cells with A overexpressed and B knocked down (siRNA) parkin cells, with and without PrP106-126, nicotinamide mononucleotide (NMN), and urolithin A (UA) treatments (Tubulin and β-actin served as loading controls.) C, D Comparisons of mitochondrial protein levels, relative to controls, in cells from A and B, respectively. Data were mean (SD). ns not significant; *P < 0.05; **P < 0.01; ***P < 0.001. All experiments were repeated at least three times.

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