Fig. 5: NMN supplementation and Parkin overexpression can alleviate PrP106-126-induced morphological mitochondrial damage and dysfunction. | Cell Death & Disease

Fig. 5: NMN supplementation and Parkin overexpression can alleviate PrP106-126-induced morphological mitochondrial damage and dysfunction.

From: PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease

Fig. 5

A Immunofluorescence images of Mito-GPF-tagged mitochondria showing differing morphologies after various treatments. Scale bar: 10 µm. B Mitochondrial ultrastructure of cells observed using transmission electron microscopy. Scale bar: 200 nm. C Comparisons of ATP levels in N2a cells. D, E Comparisons of the analyzed MMP data, as measured by changes in red/green intensity ratios, in cells in Figure S8C, D. Data were mean (SD). ns not significant; *P < 0.05; **P < 0.01; ***P < 0.001. All experiments were repeated at least three times.

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