Fig. 1: Asparaginyl endopeptidase (AEP) was upregulated in podocytes under diabetic conditions in vivo and in vitro. | Cell Death & Disease

Fig. 1: Asparaginyl endopeptidase (AEP) was upregulated in podocytes under diabetic conditions in vivo and in vitro.

From: Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

Fig. 1

Representative western blot (A) and summarized data (B) showing AEP protein levels in the kidney cortex of control (Ctrl) and streptozotocin (STZ)-induced diabetic nephropathy (DN). N = 6–9. C AEP (green) colocalization with Synaptopodin (red) in the glomeruli of control mice and DN mice, db/m mice, and db/db mice. Scale bar: 25 μm. Representative western blot (D) and summarized data (E) showing AEP protein levels in human podocytes (HPCs) treated with high glucose (HG) (final concentration 30 mmol/L), and AGE (100 μg/mL), TGF-β1 (5 ng/mL). N = 5–6. *P < 0.05, data were represented as mean ± SEM.

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